Please don't break the reply command.
Yes, spammers are annoying and obnoxious, but they haven't suceeded in breaking the internet.
If you hack your postings so that the reply address is bogus, then you are breaking the system.
Personally, I refuse to edit an email address to remove an inserted phrase like "NOSPAM". If you break reply, then I just won't reply to you.
I could go on, but why don't you just read this: